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疟疾系由不同种的疟原虫,多数由恶性疟原虫引起的一种疾病.在发展中国家,本病是主要保健问题之一.全世界4亿以上的疟疾患者中,每年死于本病者达1.5千万.近年来,由于原虫对标准抗疟药耐药性的出现,增加了疟疾控制的困难性.疟原虫与寄居细胞存在着寄生虫与细胞间的相互作用.这种相互关系的改度可影响原虫的发育.流行病学和临床研究流行病学资料表明:疟疾高发区与红细胞(RBC)遗传性疾患地区间普遍存在着地理相关性;临床研究表明:镰状细胞病的杂合子和女性G6PD缺乏的杂合子患者,对疟疾有较大的抵抗力.该发现与一般生物学理论一致,即RBC的遗传缺陷表达为平衡多态
Malaria is a disease caused by different species of Plasmodium, most of which is caused by Plasmodium falciparum. In developing countries, the disease is one of the major health problems and more than 400 million malaria patients worldwide die each year from this disease Up to 15 million in recent years, due to protozoa standard antimalarial drug resistance appears to increase the difficulty of malaria control.Plasma parasites and host cells exist parasites and cell interactions .This interrelationship Modification can affect the development of protozoa Epidemiology and clinical studies Epidemiological data show that: malaria endemic and erythrocyte (RBC) hereditary disorders prevalence of geographical correlation; clinical studies have shown that sickle cell disease miscellaneous Homozygous and female G6PD-deficient heterozygous patients have greater resistance to malaria, a finding that is consistent with the general biological theory that genetic defects in RBC are expressed as balanced polymorphisms