论文部分内容阅读
作者用全反式维甲酸（ＡＴＲＡ）治疗５５例急性早幼粒细胞白血病（ＡＰＬ），１４例出现白细胞增多症，发生率为２５．４％，其中外周血白细胞高限在２０×１０￣９／Ｌ～５０×１０￣９／Ｌ之间５例，单用ＡＴＲＡ治疗，４例获完全缓解（８０％）；白细胞高限大于５０×１０￣９／Ｌ９例，采用ＡＴＲＡ与三尖杉酯碱或羟基脲联合化疗，８例获完全缓解（８８．９％）。另外，在９例白细胞高限大于５０×１０￣９／Ｌ的病例中，５例出现白细胞滞留综合征，经治疗后４例滞留症状消失。表明ＡＴＲＡ与化疗相结合，对ＡＴＲＡ治疗期间出现的白细胞增多症是一种有效的措施，可以减低早期死亡率。
The authors treated 55 cases of acute promyelocytic leukemia (APL) with all-trans retinoic acid (ATRA), and 14 cases had leukocytosis with an incidence of 25.4%, of which the high limit of peripheral blood leukocytes was 20 x 10 ~ 9 Five patients were between /L and 50×10 ̄9/L. After treatment with ATRA alone, complete remission (80%) was achieved in 4 patients; leukocyte high limit was greater than 50×10 ̄9/L9, and ATRA and harringtonine were used. Alkali or hydroxyurea combined with chemotherapy, 8 cases were completely relieved (88.9%). In addition, in 9 cases with a leukocyte high limit greater than 50×10 ̄ 9/L, 5 patients had leukocyte retention syndrome. After treatment, the retention symptoms disappeared in 4 patients. It was shown that combining ATRA with chemotherapy is an effective measure for the leukocytosis that occurs during ATRA treatment and can reduce early mortality.