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目的:观察苦碟子注射液对90例急性脑梗死患者的血清炎症因子、疗效及生活质量的影响。方法:将2012年2月—2014年11月医院神经内科收治的180例急性脑梗死患者,按照完全随机的原则均分为观察组和对照组,观察组给予常规西医治疗,观察组在此基础上给予苦碟子注射液治疗,观察苦碟子注射液对患者的血清炎症因子、疗效及生活质量的影响。结果:观察组患者的总有效率87.8%显著高于对照组64.4%,差异具有统计学意义(P<0.05);两组患者治疗前,hs CRP及IL-18含量之间的差异无统计学意义(P>0.05);治疗后观察组患者的hs CRP及IL-18含量显著低于对照组,差异具有统计学意义(P<0.05);治疗前两组Barthel指数评分差异无统计学意义(t=3.192,P>0.05),治疗后观察组(87.37±9.428)显著高于对照组(71.82±6.134),差异具有统计学意义(t=6.504,P<0.05)。结论:苦碟子注射液能降低急性脑梗死患者的血清炎症因子(hs CRP、IL-18)的含量,提高临床治疗效果,显著改善患者的生活质量。
Objective: To observe the effect of Kudiezi Injection on serum inflammatory factors, efficacy and quality of life in 90 patients with acute cerebral infarction. Methods: 180 patients with acute cerebral infarction admitted from Department of Neurology, Department of Neurology from February 2012 to November 2014 were randomly divided into observation group and control group according to the principle of randomization. The observation group was given conventional western medicine, and the observation group was based on this principle Kudie injection on the treatment given to observe the Kusakabe injection on patients with serum inflammatory factors, efficacy and quality of life. Results: The total effective rate of observation group was 87.8%, which was significantly higher than that of control group (64.4%), the difference was statistically significant (P <0.05). There was no significant difference between the two groups before treatment, hs CRP and IL- (P <0.05). The hs CRP and IL-18 levels in the observation group were significantly lower than those in the control group after treatment (P <0.05). There was no significant difference in the Barthel index scores between the two groups before treatment t = 3.192, P> 0.05). After treatment, the observation group (87.37 ± 9.428) was significantly higher than the control group (71.82 ± 6.134), the difference was statistically significant (t = 6.504, P <0.05). Conclusion: KCD can decrease the serum levels of hs-CRP and IL-18 in patients with acute cerebral infarction, improve the clinical effect and significantly improve the quality of life of patients.