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目的探讨恒定磁场的不同强度暴露雄性小鼠某些脏器系数及血液成分的变化。方法取幼龄小鼠(4周龄),分成4组,分别放入设置有不同强度的恒定磁场(0.06、0.08、0.10 T)的鼠笼和未设置磁场的鼠笼(对照组)中24 h饲养。30 d后断颈处死小鼠,测定肝/体、脾/体和胸腺/体比值,摘眼取血进行血常规检查。结果磁暴露0.06 T组小鼠的肝/体比值、脾/体比值、白细胞数显著低于对照组(P<0.05);磁暴露0.08 T组小鼠的体质量、脾/体比值、血红蛋白数以及血小板数显著或极显著高于对照组(P<0.05,P<0.01);磁暴露0.10 T组小鼠的脾/体比值、红细胞数、血红蛋白数以及血小板极显著高于对照组(P<0.01),而胸腺/体比值、白细胞数显著低于对照组(P<0.05)。结论恒定磁场暴露会抑制雄性小鼠胸腺发育,降低白细胞数。
Objective To investigate the changes of some organ coefficients and blood components in male mice exposed to different intensities of constant magnetic field. Methods Young mice (4 weeks old) were divided into 4 groups and placed in a cage (control group) with a constant magnetic field (0.06,0.08,0.10 T) and a magnetic field-free cage h feeding. After 30 days, the mice were sacrificed and the liver / body, spleen / body and thymus / body ratio were determined. Blood was taken from the eyes and blood tests were performed. Results The liver / body ratio, spleen / body ratio and white blood cell count of 0.06 T group were significantly lower than those of the control group (P <0.05). The body weight, spleen / body ratio, hemoglobin number (P <0.05, P <0.01). The spleen / body ratio, erythrocyte number, hemoglobin and platelet in 0.10 T group were significantly higher than those in the control group (P < 0.01), while the ratio of thymus / body and leukocyte was significantly lower than that of the control group (P <0.05). Conclusion The constant magnetic field exposure can inhibit the thymus development of male mice and decrease the number of white blood cells.