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异烟肼(INH)和对氨基水杨酸(PAS)经常被联合应用于抗结核治疗。作者检查了联合应用INH和PAS时对人体内淋巴细胞染色体的作用。为了进行上述研究,筛选了Hyderaded结核病院和结核治疗中心的病人。挑选10名患者服用INH 300mg/日和PAS12g/日,最短时间为3个月。没有服上述药物的10例TB患者做为第一对照组;另取10名健康正常人做第二对照组,用Moorhead等的改良法进行末梢血培养,用Giemsa染色,标记每个患者的100个分散良好的中期分裂相,按染色单体和等臂染色单体断裂
Isoniazid (INH) and p-aminosalicylic acid (PAS) are often used in combination with antituberculous therapy. The authors examined the effect of INH and PAS on the chromosomes of lymphocytes in humans. For the above study, patients at the Hyderaded TB Hospital and Tuberculosis Center were screened. Ten patients were enrolled in INH 300mg / day and PAS12g / day, the shortest time was 3 months. 10 TB patients who did not take the above drugs as the first control group; another 10 healthy normal people as the second control group, Moorhead and other improved method for peripheral blood culture, Giemsa staining, marking each patient’s 100 A well-dispersed metaphases, broken by chromatid and isobar chromatids