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目的评价不同剂量奥美拉唑治疗功能性消化不良的疗效及安全性。方法选择2010年3月2011年6月门诊就诊的120例功能性消化不良患者,随机分为两组,小剂量组(60例)口服奥美拉唑10mg,1次/d;常规剂量组(60例)口服奥美拉唑20mg,1次/d。疗程均为4周。观察两组患者反酸、上腹痛、嗳气、餐后饱胀、气胀、呕吐等临床症状的改善程度。结果小剂量组与常规剂量组总有效率比较差异无统计学意义(P>0.05),但显效率差异有统计学意义(P<0.05),常规剂量组治疗后反酸、上腹痛、餐后饱胀、气胀症状积分改善明显优于小剂量组。两组不良反应均较轻微。结论常规剂量奥美拉唑对治疗功能性消化不良的反酸、餐后饱胀、上腹痛和气胀等临床症状的改善尤其明显,不良反应少,效果佳。
Objective To evaluate the efficacy and safety of different doses of omeprazole in the treatment of functional dyspepsia. Methods A total of 120 patients with functional dyspepsia who were treated in outpatient department in March 2011 and June 2011 were randomly divided into two groups. Small dose group (60 cases) received 10 mg omeprazole once a day. The conventional dose group 60 cases) omeprazole 20mg, 1 time / d. The course of treatment is 4 weeks. To observe the acid reflux, abdominal pain, belching, postprandial fullness, flatulence, vomiting and other clinical symptoms in both groups. Results There was no significant difference in the total effective rate between the low dose group and the conventional dose group (P> 0.05), but the significant difference was statistically significant (P <0.05) Swelling, bloating symptom scores improved significantly better than the low-dose group. Adverse reactions were mild in both groups. Conclusion The conventional dose of omeprazole is particularly effective in the treatment of functional dyspepsia such as acid reflux, postprandial fullness, upper abdominal pain and bloating. The adverse reactions are less and the effect is good.