论文部分内容阅读
目的探讨急性心肌梗死(acute myocardial infarction,AMI)患者早期应用美托洛尔片治疗的早期临床效果和经皮冠状动脉介入治疗(percutaneous transluminal coronary intervention,PCI)术前服用美托洛尔降低再灌注心律失常(reperfusion arrhythmia,RA)的发生率。方法选择2014年12月—2015年12月收治的AMI伴有RA并发症的早期患者86例,随机分为实验组44例和对照组42例,两组均使用一般常规治疗AMI的早期对症治疗,嘱患者绝对卧床休息,密切监测患者的脉搏、呼吸、血压及心电图动态变化,对照组应用阿司匹林每次100 mg,每天2次,辛伐他汀片每次10 mg,每天1次,实验组治疗基础上联用酒石酸美托洛尔每次25 mg,每天1次;两组均治疗12周,比较两组治疗效果,采用SPSS18.0软件对数据进行统计分析,计量资料组间比较采用t检验,计数资料采用χ2检验,以P<0.05为差异有统计学意义。结果实验组总有效率为93.18%高于对照组的69.04%,两组比较差异有统计学意义(χ2=8.265,P<0.05);实验组心电图改善总有效率为100.00%优于对照组的76.19%,两组比较差异有统计学意义(χ2=9.651,P<0.05);用药后72 h内实验组心率频次(70.33±5.89)次/min,低于对照组的(78.67±8.73)次/min,(P<0.05)。两组对比差异有统计学意义(t=5.215,P<0.05)。结论早期AMI患者在基本对症治疗的基础上联合美托洛尔的临床治疗效果更满意,在患者AMI早期使用美托洛尔可降低RA的概率。
Objective To investigate the early clinical effects of metoprolol tablets in patients with acute myocardial infarction (AMI) and the effects of metoprolol before percutaneous transluminal coronary intervention (PCI) The incidence of reperfusion arrhythmia (RA). Methods Eighty-six patients with AMI complicated with RA complications who were admitted from December 2014 to December 2015 were randomly divided into experimental group (n = 44) and control group (n = 42). Both groups were treated with conventional symptomatic treatment of AMI , Zhu Huanzhe absolute bed rest, close monitoring of patients with pulse, respiration, blood pressure and ECG changes in the control group aspirin 100 mg twice daily, simvastatin tablets 10 mg, 1 day, the experimental group treatment Based on the combination of metoprolol tartrate 25 mg once a day; two groups were treated for 12 weeks, the treatment effect was compared between the two groups using SPSS18.0 software for statistical analysis of data between groups using t test , Counting data using χ2 test to P <0.05 for the difference was statistically significant. Results The total effective rate in the experimental group was 93.18%, which was significantly higher than that in the control group (69.04%). There was significant difference between the two groups (χ2 = 8.265, P <0.05). The total effective rate of the experimental group was 100.00% 76.19%, there was significant difference between the two groups (χ2 = 9.651, P <0.05); within 72 hours after treatment, the heart rate frequency of the experimental group was (70.33 ± 5.89) / min which was lower than that of the control group (78.67 ± 8.73) /min, (P <0.05). The difference between the two groups was statistically significant (t = 5.215, P <0.05). Conclusion Early AMI patients are more satisfied with the clinical treatment effect of metoprolol on the basis of basic symptomatic treatment. Metoprolol can reduce the probability of RA early in patients with AMI.