少量多次给大鼠腹注顺铂（ＣＰ）及经口给予水飞蓟素葡甲胺盐（ＳＢＭＧ）预处理后给予ＣＰ，观察血尿素氮（ＢＵＮ）含量、肾皮质一氧化氮（ＮＯ）含量及一氧化氮合酶（ＮＯＳ）活性等指标的经时变化。结果发现，ＣＰ可诱导ＮＯＳ活性增高，ＮＯ生成量增多；ＣＰ所致的ＢＵＮ含量与ＮＯ含量的时相变化趋势基本一致，揭示ＮＯ可能在ＣＰ所致肾损害中起重要作用。ＳＢ可使ＢＵＮ含量与ＮＯ含量降至对照组水平，表明ＳＢ可有效地预防ＣＰ所致的肾损害，该预防作用可能与ＳＢ降低ＮＯ生成量有关 A small amount of repeated intraperitoneal injection of cisplatin (CP) and oral administration of silymarin  meglumine (SB  MG) pretreatment CP, blood urea nitrogen (BUN) content, renal cortex nitric oxide (NO ) Content and nitric oxide synthase (NOS) activity and other indicators over time. The results showed that CP could induce the increase of NOS activity and increase the production of NO. The BUN content of CP induced by CP was consistent with the phase change of NO, indicating that NO may play an important role in the renal damage induced by CP. SB can reduce the levels of BUN and NO to the level of control group, indicating that SB can effectively prevent CP-induced renal damage, which may be related to the decrease of NO production by SB