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目的探讨美托洛尔的不良反应,为临床合理用药提供参考。方法收集我院2004年1月至2008年12月美托洛尔所致不良反应病例,并进行统计分析。结果 76例不良反应中,男57例(75%),女19例(25%),年龄20～81岁,以40～69岁居多。以心血管系统不良反应所占比例最高(44.7%),接下来就是变态反应(17.1%)、神经系统不良反应(11.8%)和呼吸系统(11.8%)。结论美托洛尔的一般不良反应少见,在临床应用时,宜从小剂量开始,逐渐加量,同时观察血压、心率等的变化,一旦出现不良反应,应提高警惕,及时就医,以避免出现对身体的伤害。
Objective To investigate the adverse reactions of metoprolol and provide a reference for clinical rational drug use. Methods Metoprolol-induced adverse reactions in our hospital from January 2004 to December 2008 were collected and analyzed statistically. Results 76 cases of adverse reactions, 57 males (75%), 19 females (25%), aged 20 to 81 years old, mostly in the 40 to 69 years. Cardiovascular system accounted for the highest proportion of adverse reactions (44.7%), followed by allergies (17.1%), nervous system adverse reactions (11.8%) and respiratory system (11.8%). Conclusion Metoprolol rare adverse reactions in clinical application, it is appropriate to start small dose, the gradual increase in volume, while observing changes in blood pressure, heart rate, etc., in the event of adverse reactions, should be vigilant and timely medical treatment to avoid the emergence of Physical injury.