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人类心脏合成两种有扩张血管和利钠作用的肽类,即心房利钠肽(ANP)和脑利钠肽(BNP)。现已证明ANP主要由心房肌细胞产生并在心房舒张时释放至循环中。生理活动中(如运动、位置改变等)可影响血浆ANP水平。但是在健康人中调节心脏释放BNP的机制尚不清楚。 最近,Giuseppe Barletta等进行了一项研究评价8例健康男性成人在踏车(B)和握拳(HG)运动时的心功能及血浆ANP和BNP。每项试验之前先测静息时的情况作为对照。两种运动时均通过超声心动图评价其左室(LV)功能。只在HG时评价心房功
The human heart synthesizes two peptides that dilate blood vessels and natriuresis, atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP). It has been demonstrated that ANP is produced mainly by atrial myocytes and released into the circulation when the atrium is diastolic. Physiological activities (such as exercise, location changes, etc.) can affect plasma ANP levels. However, the mechanism by which cardiac BNP is released in healthy individuals is unclear. Recently, Giuseppe Barletta and colleagues conducted a study to evaluate the cardiac function and plasma ANP and BNP in 8 healthy male adults during treadmill (B) and clenching (HG) exercise. Before each test, measure the resting time as a control. Left ventricular (LV) function was assessed by echocardiography in both exercises. Atrial function was evaluated only at HG