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目的观察阿托伐他汀联合苯磺酸氨氯地平治疗冠心病并脑梗死对心肌酶及血脂水平的影响。方法将216例冠心病并脑梗死患者随机分为研究组和对照组各108例,在常规治疗的基础上,研究组采用阿托伐他汀联合苯磺酸氨氯地平治疗,对照组采用单纯苯磺酸氨氯地平治疗,比较2组患者治疗前后血清心肌酶(CK-MB、LDH)和血脂(TC、HDL-C、LDL-C)水平。结果治疗后2组患者CK-MB、LDH水平均较治疗前降低,且研究组低于对照组(P<0.05)。2组患者的血脂(TC、HDL-C、LDL-C)较治疗前亦有明显改善,研究组治疗后HDL-C水平高于对照组(P<0.05),TC、LDL-C水平低于对照组(P<0.05)。结论阿托伐他汀联合苯磺酸氨氯地平治疗冠心病并脑梗死较单纯使用苯磺酸氨氯地平具有更好的疗效,值得推广使用。
Objective To observe the effect of atorvastatin combined with amlodipine besylate on myocardial enzymes and serum lipids in patients with coronary heart disease and cerebral infarction. Methods 216 cases of coronary heart disease and cerebral infarction were randomly divided into study group and control group of 108 cases, on the basis of routine treatment, the study group was treated with atorvastatin combined with amlodipine besylate, the control group with benzene Amlodipine sulfonate treatment, the two groups of patients before and after treatment, serum myocardial enzymes (CK-MB, LDH) and serum lipids (TC, HDL-C, LDL-C) levels. Results After treatment, the levels of CK-MB and LDH in both groups were lower than those before treatment, and the study group was lower than the control group (P <0.05). HDL-C, HDL-C and LDL-C in the two groups were also significantly improved compared with before treatment. The levels of HDL-C in the study group were significantly higher than those in the control group (P <0.05) Control group (P <0.05). Conclusions Atorvastatin combined with amlodipine besilate in the treatment of coronary heart disease and cerebral infarction is more effective than simply using amlodipine besylate. It is worth to be used widely.