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目的：观察乳腺癌癌旁导管上皮病变，探讨与乳腺癌发生的关系及临床意义。方法：对乳腺癌手术切除标本常规取材后距离肿块周围２ｃｍ处切取６块组织，常规石蜡切片，苏木素—伊红染色，光镜观察。结果：本组乳腺癌癌旁导管上皮增生占９２．７２％，不典型增生占８９．０９％，癌变占２７．２７％。结论：乳腺导管上皮增生、不典型增生与乳腺癌发生有密切关系。部分乳腺癌为多点起源。提示临床工作者对乳腺导管上皮病变（特别是重度增生和不典型增生）患者要及时治疗、密切追踪观察，从而降低乳腺癌的发生率，并提高早期诊断率。
Objective: To observe the epithelial lesions of paracancerous ducts in breast cancer and explore the relationship and clinical significance of breast cancer. METHODS: Six specimens were obtained from 2 cm around the tumor after routine extraction of breast cancer specimens, paraffin sections, hematoxylin-eosin staining, and light microscopy. Results: In this group, paraneoplastic epithelial hyperplasia accounted for 92.72%, atypical hyperplasia accounted for 89.09%, and cancerous lesions accounted for 27.27%. Conclusions: Breast duct epithelial hyperplasia, atypical hyperplasia and breast cancer are closely related. Some breast cancers have more origins. Clinical workers are prompted to promptly treat and closely observe the lesions of breast ductal epithelium (especially severe hyperplasia and atypical hyperplasia) in order to reduce the incidence of breast cancer and improve the early diagnosis rate.