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目的:对氯吡格雷联合阿司匹林治疗急性心肌梗死的有效性与安全性进行研究,为该治疗方法的临床应用价值提供可靠依据。方法:研究对象取自于我院2013年3月~2014年3月接诊的56例急性心肌梗死患者,随机将患者均分为对照组与观察组。对照组28例患者住院期间,单纯使用阿司匹林进行治疗;观察组28例患者住院期间,使用阿司匹林联合氯吡格雷进行治疗。结果:对照组与观察组患者治疗有效率分别为:67.9%和92.9%,相较于对照组,观察组患者血管再闭塞率、再通率以及90d左右的左室射血分数明显更佳,两组对比差异有统计学意义(P<0.05)。全体患者治疗期间,均未出现任何明显不良反应。结论:氯吡格雷与阿司匹林联合治疗急性心肌梗死疗效显著,用药安全性高,适合于临床推广应用。
Objective: To study the efficacy and safety of clopidogrel plus aspirin in the treatment of acute myocardial infarction, and provide a reliable basis for the clinical value of this treatment. Methods: The subjects were from 56 patients with acute myocardial infarction admitted from March 2013 to March 2014 in our hospital. Patients were randomly divided into control group and observation group. In the control group, 28 patients were treated with aspirin alone during the hospitalization. In the observation group, 28 patients were treated with aspirin combined with clopidogrel during hospitalization. Results: The effective rates of the control group and the observation group were 67.9% and 92.9% respectively. Compared with the control group, the reperfusion rate, recanalization rate and left ventricular ejection fraction at 90 days in the observation group were significantly better, The difference between the two groups was statistically significant (P <0.05). All patients during treatment, did not show any significant adverse reactions. Conclusion: The combination therapy of clopidogrel and aspirin has significant curative effect on acute myocardial infarction. The drug is safe and suitable for clinical popularization and application.