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丙戊酸钠(sodium valproate)是神经外科围手术期预防及治疗术后早期癫痫的首选药物,具有疗效肯定、不良反应少、剂型全的特点,其有效的血药浓度范围为50～100μg·mL~(-1)~[1]。比阿培南(biapenem)是新型1β-甲基碳青霉烯类抗生素,对革兰阴性菌(G~-)及革兰阳性菌(G~+)均具有广谱且优异的抗菌效果,并且对超广谱β-内酰胺酶
Sodium valproate is the first choice of perioperative neurosurgical prophylaxis and treatment of postoperative epilepsy. It has definite curative effect, few adverse reactions, and complete dosage form. Its effective plasma concentration ranges from 50 to 100 μg · mL ~ (-1) ~ [1]. Biapenem is a novel 1β-methylcarbapenem antibiotic with broad-spectrum and excellent antibacterial activity against Gram-negative bacteria (G ~ -) and Gram-positive bacteria (G ~ +) And for extended spectrum β-lactamase