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1990年Issemann和Green首次发现并从小鼠肝脏克隆了一种新的甾体激素受体,当时因其结构与糖皮质激素受体等核受体家族类似,且未能证实其配体,称之为孤儿受体。后来研究证明一些能导致过氧化物酶体增殖物激活受体增多
In 1990, Issemann and Green first discovered and cloned a new steroid hormone receptor from mouse liver when its structure was similar to the nuclear receptor family such as the glucocorticoid receptor and failed to confirm its ligand Orphan receptors. Later studies have shown that some can lead to peroxisome proliferator-activated receptor increased