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目的观察潘妥拉唑联用抗生素治疗幽门螺杆菌(Hp)阳性十二指肠溃疡的临床疗效。方法将62例患者随机分为治疗组(潘妥拉唑组)32例和(奥美拉唑组)30例,并同时加用克拉霉素和甲硝唑进行治疗,停药后4周复查胃镜及Hp检测。方法治疗4周后,治疗组和对照组Hp根除率分别为90.6%(29/32)和90.0%(27/30)(P>0.05);治疗组和对照组溃疡愈合率分别为93.8%(30/32)和93.3%(28/30)(P>0.05)。治疗组腹痛缓解率96.9%(31/32)明显高于对照组83.3%(25/30),两组差异有显著性(P<0.05)。结论潘妥拉唑有较高的溃疡愈合率和Hp根除率,止痛效应快,不良反应发生率较低。
Objective To observe the clinical efficacy of pantoprazole combined with antibiotics in the treatment of Helicobacter pylori (Hp) -positive duodenal ulcer. Methods Totally 62 patients were randomly divided into treatment group (ptolazole group) 32 cases and (omeprazole group) 30 cases, and at the same time with clarithromycin and metronidazole for treatment, 4 weeks after drug withdrawal review Gastroscopy and Hp testing. After 4 weeks of treatment, the eradication rates of Hp in the treatment group and the control group were 90.6% (29/32) and 90.0% (27/30) respectively (P> 0.05). The healing rates of the ulcer in the treatment group and the control group were 93.8% 30/32) and 93.3% (28/30) (P> 0.05). The rate of relieving abdominal pain in the treatment group was significantly higher than that in the control group (96.9%, 31/32) (83.3%, 25/30). There was significant difference between the two groups (P <0.05). Conclusions PTP has higher ulcer healing rate and Hp eradication rate with faster analgesic effect and lower incidence of adverse reactions.