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应用庆大霉素（ＧＭ）和卡那霉素（ＫＭ）分别对小鸡和鹌鹑进行了耳毒性对比研究。扫描电镜（ＳＥＭ）观察显示，在ＧＭ８０ｍｇ／ｋｇ剂量下，１０天龄小鸡内耳毛细胞遭到严重破坏，而４０天龄鹌鹑则无明显变化；鹌鹑内耳对ＫＭ比对ＧＭ相对敏感，但引起鹌鹑内耳中毒的ＫＭ剂量（３５０～４００ｍｇ／ｋｇ）已相当于哺乳动物的内耳中毒剂量；而小鸡和鹦鹉则只需该剂量的１／２即可造成内耳严重破坏。表明小鸡与鹌鹑对此类抗生素的内耳反应存在着较大的种属差异。了解这一现象对于开展鸟类毛细胞再生研究乃至神经性聋的临床治疗将具有推动作用。
The ototoxicity of chickens and quails was studied by gentamicin (GM) and kanamycin (KM) respectively. Scanning electron microscopy (SEM) observations showed that hair cells in the inner ear of 10-day-old chickens were severely damaged at a dose of 80 mg / kg GM, while there was no significant change in the 40-day-old quails. The inner ear of quail was more sensitive to KM than to GM, KM doses of quail inner ear poisoning (350-400 mg / kg) have been equivalent to the mammalian inner ear poisoning dose; while chickens and parrots only require 1/2 of the dose to cause severe damage to the inner ear. Indicating that chickens and quails on such antibiotics within the inner ear reaction there is a big species difference. To understand this phenomenon for the conduct of bird hair cell regeneration and even the clinical treatment of nerve deafness will play a catalytic role.