目的探讨检测急性脑梗死(ACI)患者纤维蛋白原(Fg)、D-二聚体(DD)和血管性血友病因子抗原(vWF Ag)的临床价值。方法选取94例ACI患者作为脑梗死(A)组,检测治疗前后Fg、DD和vWF Ag变化;同期94例非血栓性疾病患者作为对照(B)组。分析三项指标对ACI的诊断价值。结果 A组治疗前血浆Fg、DD和vWF Ag值高于B组(P<0.05),治疗后降低(P<0.05)。取Fg>4.5g/L、DD>131μg/L、vWF Ag>142%为截断值,Fg、DD和vWF Ag诊断ACI的特异度分别为90%、78%和77%,灵敏度分别为21%、50%和82%,准确性分别为60%、65%和80%。结论检测血浆Fg、DD和vWF Ag对ACI诊断均有一定临床价值,以vWF Ag的准确性最高。 Objective To investigate the clinical value of detecting fibrinogen (Fg), D-dimer (DD) and von Willebrand factor antigen (vWF Ag) in patients with acute cerebral infarction (ACI). Methods Ninety-four patients with ACI were enrolled as group A, and the changes of Fg, DD and vWF Ag before and after treatment were detected. In the same period, 94 patients with non-thrombotic disease were selected as control group (B). Analysis of three indicators of the diagnostic value of ACI. Results The plasma levels of Fg, DD and vWF Ag in group A before treatment were significantly higher than those in group B (P <0.05), and decreased after treatment (P <0.05). The specificity of Fg, DD and vWF Ag for the diagnosis of ACI were 90%, 78% and 77%, respectively, with Fg> 4.5g / L, DD> 131μg / L and vWF Ag> 142% , 50% and 82% with accuracy of 60%, 65% and 80% respectively. Conclusion The detection of plasma Fg, DD and vWF Ag have certain clinical value in the diagnosis of ACI, and the accuracy of vWF Ag is the highest.