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为了探讨胰岛素依赖型糖尿病(IDDM)患者外周血 T 淋巴细胞亚群的变化,本文采用单克隆抗体技术测定了35例 IDDM 患者的外周血 T 细胞亚群,同时测定了胰岛素抗体和糖基化血红蛋白(GHb),发现早期 IDDM 患者CD_3,CD_8阳性细胞数明显低于对照组(P<0.01);CD_4/CD_8值显著高于对照组(P<0.01)。随病程延长这种变化逐渐消失(P<0.05)。早期 IDDM 患者 CD_4/CD_8值与 GHb 呈中度正相关(r=0.5684)。可见,外周血 T 淋巴细胞亚群的失衡是IDDM 发病的一个重要因素,其失衡程度与早期病程呈正相关。
In order to investigate the changes of T lymphocyte subsets in peripheral blood of patients with insulin-dependent diabetes mellitus (IDDM), T lymphocyte subsets of 35 IDDM patients were determined by monoclonal antibody technique. The levels of insulin antibody and glycosylated hemoglobin (GHb). The number of CD_3 and CD_8 positive cells in IDDM patients was significantly lower than that in control group (P <0.01). The CD_4 / CD_8 was significantly higher than that in control group (P <0.01). With the extended duration of this change gradually disappeared (P <0.05). There was a moderate positive correlation between CD_4 / CD_8 and GHb in early IDDM (r = 0.5684). Can be seen that the imbalance of peripheral blood T lymphocyte subsets is an important factor in the pathogenesis of IDDM, the degree of imbalance and the early course of a positive correlation.