The open-close mechanism of M2 channel protein in influenza A virus:A computational study on the hyd

来源 :中国科学：化学英文版 | 被引量 : 0次 | 上传用户：wei2859699

【摘要】

：

The M2 protein from influenza A virus is a tetrameric ion channel. It was reported that the permeation of the ion channel is correlated with the hydrogen bond n

【作者】

：

JiaGao Cheng (1) WeiLiang Zh

【机构】

：

1.SchoolofPharmacy,2.DrugDiscoveryandDesignCenter,3.SchoolofSciences

【出处】

：

中国科学：化学英文版

【发表日期】

：

2008年8期

【关键词】

：

cation-π INTERACTION hydrogen bond NONCOVALENT INTERACTION ab INITIO calculation

【基金项目】

：

Supported by the National Natural Science Foundation of China (Grant No. 20572117),the Shanghai Postdoctoral Scientific Program (Grant No. Y200-2-08)

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The M2 protein from influenza A virus is a tetrameric ion channel. It was reported that the permeation of the ion channel is correlated with the hydrogen bond network among His37 residues and the cation-π interactions between His37 and Trp41. In the prese

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