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调强适形放疗(IMRT)能更好地提高靶区剂量,减少靶区周围正常组织的剂量,特别适宜头颈部这些比较靠近重要器官的肿瘤的治疗。在头颈部肿瘤的治疗中,IMRT比常规放疗有更好的剂量分布优势,在不影响肿瘤控制率和无瘤生存率的情况下,能够降低临近重要器官毒性,从而降低脑、脊髓损伤以及口干等副作用的发生率。IMRT显著提高了靶区的覆盖范围和避开正常组织,然而在头颈部肿瘤的治疗中局部复发依然是治疗失败的主要原因。分析了1999年以来关于头颈部肿瘤局部复发的文献资料,对使用IMRT治疗头颈部肿瘤病人的局部复发问题进行综述。
Intensity modulated radiation therapy (IMRT) can better improve the target dose, reduce the normal tissue around the target dose, especially for head and neck of these relatively close to the treatment of important organs of the tumor. In the treatment of head and neck cancer, IMRT has a better dose distribution advantage than conventional radiotherapy and can reduce the toxicity of nearby vital organs without affecting tumor control rate and tumor-free survival rate, thereby reducing brain and spinal cord injury and Dry mouth and other side effects of the incidence. IMRT significantly increases the coverage of the target area and avoids normal tissue. However, local recurrence in the treatment of head and neck cancer remains a major cause of treatment failure. The literature about local recurrence of head and neck cancer since 1999 is analyzed, and the local recurrence of head and neck cancer patients treated with IMRT is reviewed.