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Objective:To investigate the effects of IMPX977 on long term potentiation(LTP)at Schaffer collateral-CA1 synapses in vitro and on methyl CpG binding protein 2(Mecp2)expression in mice cortex and hip-pocampus.Methods:Thirty-two C57BL/6 mice were randomly divided into four groups:control,olive oil(vehicle),IMPX977 low(5 mg/kg)and high(15 mg/kg)groups.Mice were administrated every other day orally for two weeks.Extracellular recording technique in vitro was used to record the effects of IMPX977 on Schaffer collateral-CA1 LTP pathway in acute mice hippocampal slices.The Mecp2 protein expression level was detected by Western blotting.Results:Compared to the control group,vehicle did not alter the synaptic transmission in Schaffer collateral-CA1 synapses,however,IMPX977 at concentrations of 5 mg/kg and 15 mg/kg significantly enhanced fEPSP(field excitatory postsynaptic potential)slope in Schaffer collateral-CA1 pathway to(179.6 ± 17.8)％and(191.4 ± 21.4)％,individually 60 min after HFS,IMPX977 improved LTP induction sig-nificantly at Schaffer collateral-CA1 pathway at least.Also,IMPX977 significantly elevated MeCP2 protein level in cortex.Conclusion:The effects of IMPX977 on synaptic transmission and Mecp2 protein expression provided convincing evidence that IMPX977 could be promising new drug candidates for Rett syndrome treatment.