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目的应用实验室免疫血清学方法监测合肥市流行性脑脊髓膜炎(流脑)患者感染状况以及易感人群免疫水平。方法采用回顾性诊断研究模式,采集合肥市辖区内医疗机构流脑监测病例急性期、恢复期双份血清,应用酶联免疫吸附试验分析患者流脑感染状况,通过急性期抗体浓度研究易感人群免疫水平。结果2005-2008年流脑流行季节流脑监测病例数186份,C群流脑病例检出率72.6%(135份)。易感人群急性期C群脑膜炎奈瑟菌(Nm)抗体浓度大于2μg/m l组监测病例数为29份,Nm抗体阳性病例1份,阳性率3.4%(1/29)。结论在合肥市流脑监测病例中流脑感染以C群Nm为主,易感人群急性期抗体浓度大于2μg/m l时有明显保护性。
Objective To detect the infection status of patients with epidemic cerebrospinal meningitis (Hemo-cerebrospinal meningitis) in Hefei and the immunological level of susceptible people by laboratory immunological serological method. Methods A retrospective diagnostic study was conducted in this study. Serum was collected from acute and convalescent patients in medical institutions in Hefei City. Enzyme - linked immunosorbent assay (ELISA) was used to analyze the meningococcal meningococcal infection in the patients. The susceptible population Immunization level. Results In 2005-2008, there were 186 epidemic cerebrospinal-cerebrospinal-cerebrospinal-meningistic surveillance cases and 72.6% (135) cases of group C meningitis. Susceptible population A group of Neisseria meningitidis (Nm) antibody concentration greater than 2μg / m l group of 29 cases were detected in the acute phase, Nm antibody positive cases in 1, the positive rate of 3.4% (1/29). Conclusion The prevalence of meningococcal meningitis in Hepatitis B patients in Hefei is mainly C group Nm, which is obviously protective when the concentration of antibody is more than 2μg / m L in susceptible population.