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目的评价浙江省嵊泗县疫苗接种效果和人群免疫水平情况。方法随机抽取健康人群248名(包括个别外来流动人群)开展了人群麻疹、百日咳、白喉、破伤风抗体水平监测分析,用微量血球凝集抑制试验检测麻疹特异性IgG抗体,用试管凝集试验检测百日咳凝集抗体,用间接血凝试验检测白喉抗毒素和破伤风抗毒素。结果本次检测健康人群麻疹血清抗体阳性率为72.18%;百日咳血清抗体阳性率为80.74%,保护率为32.38%;白喉血清抗体阳性率为阳性率为54.25%;破伤风抗毒素达保护水平占72.18%。结论当前人群疫苗免疫保护水平尚有不足,可能与个别外来流动儿童未完成全程接种,个别疫苗接种程序、剂量改变以及海岛疫苗运输冷链条件差,个别批次疫苗质量是否可能下降等因素相关,值得进一步探讨。
Objective To evaluate the effect of vaccination and population immunity in Shengsi County, Zhejiang Province. Methods A total of 248 healthy individuals (including individual migrants) were randomly selected to monitor measles, pertussis, diphtheria and tetanus antibody levels. Measles-specific IgG antibodies were detected by microagglutination inhibition assay. Tuberculosis agglutination test Antibodies were tested for diphtheria antitoxin and tetanus antitoxin using an indirect hemagglutination test. Results The positive rate of measles serum antibody in healthy people was 72.18%. The positive rate of serum antibody of pertussis was 80.74% and the protection rate was 32.38%. The positive rate of diphtheria serum antibody was 54.25%. The protection level of tetanus antitoxin reached 72.18%. %. Conclusions There is still a lack of vaccine immunization in the current population, which may be related to the incomplete vaccination of individual migrant children, individual vaccination procedures, dose changes, poor cold chain condition of island vaccine transport, and the possibility of individual vaccine quality declines. Worth further exploration.