目的评价哌拉西林他唑巴坦(联邦他唑仙)治疗下呼吸道感染的临床疗效和安色性。方法82例下呼吸道感染患者随机分为治疗组41例和对照组41例,分别应用哌拉西林他唑巴坦4·5g和头孢他啶2·0g治疗,每天2次,平均用药10d,并进行了临床观察。结果哌拉西林他唑巴坦和头孢他啶临床有效率分别为93%和91%,细菌清除率分别为86%和85%,不良反应发生率均为2%。结论哌拉西林他唑巴坦对治疗下呼吸道细菌感染临床疗效较好,而且不良反应发生率较低。 Objective To evaluate the clinical efficacy and safety of piperacillin / tazobactam in the treatment of lower respiratory tract infections. Methods 82 patients with lower respiratory tract infection were randomly divided into treatment group 41 cases and control group 41 cases, respectively, piperacillin and tazobactam 4.5 g and ceftazidime 2.0 g twice daily for 10 days on average Clinical Observation. Results The clinical efficacies of piperacillin and tacrolimus were 93% and 91% respectively, the bacterial clearance rate was 86% and 85% respectively, and the incidence of adverse reactions was 2%. Conclusion Piperacillin and tazobactam are effective in treating bacterial infections of lower respiratory tract, and the incidence of adverse reactions is low.