自埃尔利克(Ehrlich)1887年提出血脑屏障这个概念以后,人们对它的认识不断提高。特别是近二、三十年来,应用电镜及酶标记法的研究,把血脑屏障的形态与机能的概念提高到新的水平,奠定了与之有关的临床诊治方面一些问题的理论基础,为许多中枢神经疾患的治疗提供了依据。现概述如下。一、血脑屏障的形态学基础近年电镜及酶标记法研究发现,血脑屏障的基础组织是脑的毛细管内皮细胞层,此层细胞具有联接紧密和胞饮作用弱的特点,形象地说,脑毛细管内皮细胞之间如条焊联接,它几乎无空隙,因而可以阻挡2纳米(nm)以上物质透过,而一般毛细管的内皮细胞之间则似点焊,点焊之间有相当大的缝 Since Ehrlich put forward the concept of the blood-brain barrier in 1887, people’s awareness of it has been constantly increasing. Especially in the past two or three decades, the application of electron microscopy and enzymatic labeling has brought the concept of the shape and function of the blood-brain barrier to a new level, laying a theoretical foundation for some problems in clinical diagnosis and treatment. Many central nervous diseases provide the basis for the treatment. Now summarized as follows. First, the morphological basis of the blood-brain barrier In recent years, electron microscopy and enzyme-labeled study found that the basic organization of the blood-brain barrier is the capillary endothelial cell layer of the brain, the layer cells with a weak connection and the characteristics of weak, vividly, Capillary capillary endothelial cells such as the connection between the strip, it is almost no voids, which can block the 2 nm (nm) and more substances through, and the general capillary endothelial cells are like spot welding, spot welding between considerable Sew