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目的探讨血清载脂蛋白B(ApoB)水平与颈动脉斑块、冠状动脉粥样病变及其严重程度的关系。方法 248例行冠脉造影检查的住院患者根据冠脉造影结果分为单支病变组(59例)、多支病变组(107例)和对照组(82例),比较血清ApoB水平在各组中的变化,分析血清ApoB水平与颈动脉斑块、冠脉狭窄严重程度的相关性。结果①冠心病单支病变组血清ApoB(1.09±0.25 g/L vs 0.69±0.18 g/L,P<0.05)和多支病变组血清ApoB(1.99±0.11 g/L vs0.69±0.18 g/L,P<0.01)显著高于对照组,且多支病变组血清ApoB水平较单支病变组差异有统计学意义(1.09±0.25g/L vs 1.99±0.11 g/L,P<0.05);②冠心病单支病变组和多支病变组颈动脉易损斑块的发生率(20.3%、23.4%vs7.3%,P<0.05)与对照组相比明显增高;③血清ApoB水平与冠心病颈动脉易损斑块发生率(r=0.482,P<0.05)呈显著正相关,与冠脉积分(r=0.563,P<0.05)亦呈显著正相关。结论血清ApoB水平反映了动脉粥样硬化的程度,与冠脉病变严重程度密切相关。
Objective To investigate the relationship between serum apolipoprotein B (ApoB) level and carotid plaque, coronary atherosclerosis and its severity. Methods 248 inpatients undergoing coronary angiography were divided into single lesion group (59 cases), multi-vessel lesion group (107 cases) and control group (82 cases) according to coronary angiography results. Serum ApoB levels were compared between groups In the changes of serum ApoB levels and carotid plaque, the severity of coronary stenosis correlation. Results ① The serum level of ApoB (1.09 ± 0.25 g / L vs 0.69 ± 0.18 g / L, P <0.05) and multi-vessel disease group (1.99 ± 0.11 g / L vs 0.69 ± 0.18 g / L, P <0.01) was significantly higher than that of the control group. The level of ApoB in the multi - vessel disease group was significantly different from that in the single vessel disease group (1.09 ± 0.25 g / L vs 1.99 ± 0.11 g / L, P <0.05). ② The incidence of carotid artery vulnerable plaque in single vessel disease group and multiple vessel disease group was significantly higher than that in control group (20.3% vs 23.4% vs 7.3%, P <0.05) Coronary heart disease vulnerable plaque incidence (r = 0.482, P <0.05) was positively correlated, and coronary artery integral (r = 0.563, P <0.05) also showed a significant positive correlation. Conclusions Serum ApoB level reflects the degree of atherosclerosis and is closely related to the severity of coronary artery disease.