目前抗结核化疗多主张联合用药,开始就用几种较强的杀菌药予细菌以进攻性杀灭,即“强化治疗”。因此,在治疗中除掌握各药的作用特点及毒副反应外,了解药物之间的相互作用对合理用药尤其重要。抗结核药的相互作用1.异烟肼(INH)是在肝内经乙酰移换酶的催化,其氨基与乙酰辅酶 A 反应生成乙酰异烟肼而灭活。利幅平(RFP)系强力药酶诱导剂,能加速 INH 的代 At present, many anti-tuberculosis chemotherapy advocates the combination of drugs, began to use several strong bactericidal drugs to bacteria to kill off, that is, “intensive treatment.” Therefore, in addition to the treatment of the role and characteristics of toxic drugs and side effects, to understand the interaction between drugs for rational use of drugs is particularly important. Antituberculosis Drug Interactions 1. Isoniazid (INH) is catalyzed by acetyltransferases in the liver and its amino group is inactivated by the reaction with acetyl-CoA to form acetyl isoniazid. Ripin (RFP) is a powerful drug inducer that accelerates the generation of INH