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目的探讨胃癌卵巢转移的临床特征、治疗及影响预后的因素。方法对收治的经组织病理学及影像学确诊的胃癌卵巢转移62例患者进行生存时间分析,经Kaplan-Meier生存分析,Cox回归分析等方法,探讨影响胃癌卵巢转移患者的相关预后因素。结果该组胃癌卵巢转移患者中位年龄44岁,双侧卵巢转移24例(38.7%),30例(48.4%)的肿瘤组织学类型为印戒细胞癌。均采用了手术联合化疗为主的综合治疗。全组中位生存期为15.6个月。1、2、3年生存率分别为71.8%、16.7%和3.6%。Cox单因素及多因素回归分析表明:患者年龄与预后呈相反趋势(P<0.05)。结论胃癌卵巢转移患者预后较差,年龄是独立的危险因素。化疗方案的选择可以改善患者预后。
Objective To investigate the clinical characteristics, treatment and prognosis of gastric cancer with ovarian metastasis. Methods The survival time of 62 patients with metastatic gastric cancer confirmed by histopathology and imaging was analyzed. Kaplan-Meier survival analysis and Cox regression analysis were used to explore the prognostic factors of ovarian metastasis. Results The median age of the patients with metastatic gastric cancer was 44 years, and that of bilateral ovarian metastases was 24 (38.7%) and 30 (48.4%) were signet ring cell carcinomas. Have adopted a combination of chemotherapy-based comprehensive treatment. The median overall survival was 15.6 months. The 1, 2, 3 year survival rates were 71.8%, 16.7% and 3.6% respectively. Cox univariate and multivariate regression analysis showed that the age and prognosis of patients showed the opposite trend (P <0.05). Conclusion The prognosis of patients with gastric cancer with ovarian metastasis is poor, and age is an independent risk factor. The choice of chemotherapy regimen can improve patient outcomes.