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头孢噻吩钠对革兰阳性菌活性较强,不产青霉素酶和产青霉素酶金葡菌、凝固酶阴性葡萄球菌、B组溶血性链球菌等对本品皆相当敏感。肠球菌属、耐甲氧西林葡萄球菌、李斯特菌和奴卡耐药菌等对本品高度敏感,部分大肠埃希菌、克雷伯菌属、沙门菌属等对本品多中度敏感,其余革兰阴性菌则多数耐药。革兰阳性菌对本品敏感。本研究对其含量测定方法进行了方法学验证,然后对其与部分溶媒配伍在不同时间的pH值、含量、外观进行稳定性考察,为临床合理用药提供依据。
Cefalothione sodium Gram-positive bacteria activity is strong, non-penicillinase and penicillinase-producing Staphylococcus aureus, coagulase-negative staphylococci, B hemolytic streptococcus, etc. are very sensitive to the goods. Enterococcus, methicillin-resistant Staphylococcus aureus, Listeria monocytogenes and other drug-resistant highly sensitive to this product, part of Escherichia coli, Klebsiella, Salmonella and other more moderate sensitivity to the goods , The rest of Gram-negative bacteria are most resistant. Gram-positive bacteria sensitive to the goods. In this study, its content determination method was verified by methodology, and then its compatibility with some solvents at different times of pH value, content, appearance stability study to provide the basis for clinical rational use of drugs.