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转化生子因子β_1(TGF-β_1)是多肽生长因子家族中的一员,在各种病因导致肝损伤后,TGF-β_1可活化肝星状细胞而起动肝纤维化进程,并通过促进细胞外基质合成,抑制其降解,使肝脏发生纤维沉积,还通过对其它多种细胞和细胞因子的广泛影响,使肝纤维化不断进展。TGF-β_1水平可很好地反映肝纤维化的状况,针对TGF-β_1的治疗研究为抗肝纤维化开辟了一条新途径。
Transforming growth factor β_1 (TGF-β_1) is a member of the polypeptide growth factor family. TGF-β_1 can activate hepatic stellate cells and initiate hepatic fibrosis after various pathologies lead to liver injury. By promoting extracellular matrix Synthesis, inhibition of its degradation, the occurrence of fiber deposition in the liver, but also through a wide range of other cells and cytokines, the continuous progress of liver fibrosis. The level of TGF-β_1 can well reflect the status of liver fibrosis, and the treatment of TGF-β_1 has opened up a new way for anti-liver fibrosis.