目的　了解两性畸形儿的染色体异常情况及其它病因。方法　利用常规外周血淋巴细胞染色体标本制备、G显带技术和询问调查等方法。结果　染色体核型异常者 15例 ,占所分析病因的 2 7%。其发病病例有 8例为孕期保胎使用激素 ,占 14% ;2 5例是为了生男孩于孕早期服药所致 ,占 44 % ;8例病因不明 ,占 15 %。结论　性染色体异常是导致性分化异常的重要原因之一。 Objective To understand the chromosomal abnormalities and other causes of amphiprotic children. Methods The routine preparation of peripheral blood lymphocyte chromosome specimens, G-banding techniques and inquiry investigation methods. Results There were 15 cases of abnormal chromosome karyotype, accounting for 27% of the analyzed etiology. The incidence of cases of 8 cases of pregnancy-specific use of hormones, accounting for 14%; 25 cases are due to the first trimester of medication in boys, accounting for 44%; 8 cases of unknown etiology, accounting for 15%. Conclusions Sexual chromosomal abnormalities are one of the important causes of abnormal differentiation.