拉丁语de novo(重新、开始之意),是指癌不经过特定的良性病变或癌前病变,直接从正常粘膜发生的一个专用术语。本文作者主张人类的大肠癌有半数以上系由de novo所发生,其形态较为平坦, 对大肠癌的产生原因,至今仍未取得一致的看法。Morson认为,大肠癌起源于息肉、腺瘤及发育异常,否认由(denovo)进一步发展而来。Kuramoto等将切除的大肠全部制成切片,证实了微小的de novo所致大肠癌的存在。对于Kuramoto等的报告,Tass等则认为 Latin de novo (renew, beginning meaning) refers to a specific term that occurs directly from the normal mucosa without undergoing specific benign lesions or precancerous lesions. The author of this paper argues that more than half of human colorectal cancers are caused by de novo, and their morphology is relatively flat. There is still no consensus on the causes of colorectal cancer. Morson believes that colorectal cancer originated from polyps, adenomas, and dysplasia, and denied denovo development. Kuramoto et al. made all cut large intestines into slices, confirming the presence of tiny de novo-induced colon cancer. For the report of Kuramoto et al., Tass et al.