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用微量热法研究一种新型希夫碱及其3d,4f配合物(2L,2LZnYb)对大肠杆菌和金黄色葡萄球菌的抗菌活性,得到了在它们作用下大肠杆菌和金黄色葡萄球菌生长代谢的产热曲线,并且基于分析生长代谢和非生长代谢的产热曲线建立的热动力学方程,获得了它们的抗菌活性.结果表明,两种化合物(ZL,2LZnYb)对大肠杆菌的生长代谢有强的活性(IC50分别为6.1和5.1mg·L-1),但对金黄色葡萄球菌的生长代谢的活性弱得多(IC50分别为310.1和595.5mg·L-1).Zn和Yb的导入使化合物对大肠杆菌生长代谢的抑制作用稍微增加,但大大降低了对金黄色葡萄球菌的抑制作用.对于非生长代谢,两种化合物的活性有很大的差别.无论对大肠杆菌还是金黄色葡萄球菌,由于配体2L的导入,表现出显著的抑制作用,2L的MSC50为6.4和209.7mg·L-1.配体2L可能成为新的抗菌先导化合物.
The antibacterial activity of a novel Schiff base and its 3d, 4f complex (2L, 2LZnYb) against Escherichia coli and Staphylococcus aureus was studied by microcalorimetry. The growth and metabolism of Escherichia coli and Staphylococcus aureus And their antimicrobial activities were obtained based on the thermodynamic equations established by the analysis of the thermo-kinetic curves of growth metabolism and non-growth metabolism.The results showed that the two compounds (ZL, 2LZnYb) had no effect on the growth and metabolism of E. coli (IC50 = 6.1 and 5.1 mg · L-1, respectively), but the activity of Staphylococcus aureus was much weaker (IC50: 310.1 and 595.5 mg · L-1, respectively) So that compounds inhibit the growth and metabolism of E. coli slightly increased, but greatly reduced the inhibition of Staphylococcus aureus.For non-growing metabolism, the activity of the two compounds are very different.Either for E. coli or golden yellow grape The cocci showed significant inhibition due to the introduction of 2L of ligand, and the 2L MSC50 was 6.4 and 209.7 mg · L -1, and the ligand 2L could be the new antimicrobial lead compound.