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目的探讨低分子肝素联合复方丹参滴丸治疗妊娠中晚期脐动脉血流异常的临床效果。方法将89例妊娠中晚期脐动脉血流异常的患者,按治疗方案不同分为两组,对照组给予低分子肝素治疗;观察组加用复方丹参滴丸治疗。观察两组治疗前后脐血流变化及凝血功能的变化。结果两组孕妇治疗后S/D比值、PI、RI均明显降低,与治疗前比较差异均有统计学意义;对照组凝血指标搏动指数与观察组比较差异有统计学意义(P<0.001);观察组患者治疗后脐动脉血流S/D比值下降速度及治疗时间均优于对照组(P<0.001或P<0.01)。结论低分子肝素联合复方丹参滴丸治疗妊娠中晚期脐动脉血流异常,可改善胎盘血流,且S/D比值下降速度快,对凝血功能无影响,值得推广应用。
Objective To investigate the clinical effect of low molecular weight heparin combined with compound Danshen dripping pills in treatment of umbilical artery abnormalities in middle and late pregnancy. Methods Eighty-nine patients with umbilical artery abnormalities in the second trimester of pregnancy were divided into two groups according to different treatment regimens. The control group was given low molecular weight heparin. The observation group was treated with compound Danshen dripping pills. Changes of umbilical blood flow and coagulation function before and after treatment were observed. Results The S / D ratio, PI and RI of the two groups of pregnant women after treatment were significantly lower than those before treatment, and the difference was statistically significant (P <0.001) between the control group and the observation group. The rate of decline of S / D ratio in umbilical artery blood flow and the treatment time in observation group were better than those in control group (P <0.001 or P <0.01). Conclusion Low molecular weight heparin combined with compound Danshen dripping pills can treat abnormalities of umbilical arterial blood flow in the middle and late pregnancy, which can improve the blood flow of the placenta. The S / D ratio declines rapidly and has no effect on the coagulation function, which is worth popularizing and applying.