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观察了静推２０％甘露醇对兔耳缘静脉的影响，病理检查显示，注射２次时，甘露醇与生理盐水组无明显差别，注射４次及８次时，在穿刺部位及距穿刺点１ｃｍ处，甘露醇组血管及其周围组织病理损害加重。主要表现为血管壁增厚，内皮细胞破坏，血管内瘀血，周围组织炎症及水肿等。注射８次后５天与１０天的结果显示，两组恢复程度基本一致，即周围组织炎症及水肿的消失。研究结果提示，甘露醇易导致血管损害且不易恢复，因此不宜在同一部位反复注射，其机制可能与甘露醇的高渗性有关。
The effect of intravenous injection of 20% mannitol on the rabbit ear veins was observed. Pathological examination showed no significant difference between the mannitol and the saline group after injection for 2 times. At the puncture site and at the puncture site 1cm Department, mannitol group of blood vessels and their surrounding tissue pathological lesions worsened. The main manifestations of vascular wall thickening, endothelial cell damage, blood stasis within the blood vessels, peripheral tissue inflammation and edema. The results of 5 days and 10 days after 8 injections showed that the recovery of the two groups was basically the same, that is, the disappearance of inflammation and edema in the surrounding tissues. The results suggest that mannitol easily lead to vascular damage and not easy to recover, it should not be injected repeatedly in the same place, the mechanism may be related to hypertonic mannitol.