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目的探讨卵巢恶性苗勒管混合瘤的临床病理特点及鉴别诊断。方法复习6例卵巢恶性苗勒管混合瘤患者的临床资料,行常规石蜡切片和免疫组化染色。结果恶性苗勒管混合瘤镜下肿瘤成分复杂,形态多样,由上皮和间叶两种成分构成,相互间有穿插及移行。免疫组化:腺上皮CK(+),间质成分vimentin(+);2例ER(+),1例PR(+);CD34和desmin(-)。结论卵巢恶性苗勒管混合瘤诊断主要依赖组织学形态,临床主要与不成熟畸胎瘤相鉴别。
Objective To investigate the clinicopathological features and differential diagnosis of malignant Müllerian mixed tumor in ovary. Methods The clinical data of 6 patients with malignant Müllerian mixed tumor of ovary were reviewed. The paraffin sections and immunohistochemical staining were performed. Results Malignant Mullerian tumor mixed tumor microscopic tumor composition is complex and diverse forms, composed of epithelial and mesenchymal two components, interspersed with each other and migration. Immunohistochemistry: gland epithelial CK (+), interstitial vimentin (+); 2 ER (+), 1 PR (+); CD34 and desmin (-). Conclusions The diagnosis of ovarian malignant Müllerian mixed tumor mainly depends on the histological morphology, which is mainly differentiated from immature teratoma.