用骨髓移植治疗红细胞系疾病并不多,用骨髓移植治疗重症地中海贫血,疗效令人鼓舞。本文报道用同种骨髓移植治疗4例先天性纯红细胞再障,旨在对移植前的预处理方案、疗效及安全性进行探索。病人和方法骨髓供者均为人类白细胞抗原(HLA)相同,混合淋巴细胞培养(MLC)阴性的兄弟或姐妹。受者为长期规则接受输血治疗至少5年,对肾上腺皮质激素治疗无效的先天性纯红细胞再障患 Bone marrow transplantation for the treatment of red blood cell disease is not much, with bone marrow transplantation for treatment of severe thalassemia, the effect is encouraging. This article reports the use of allogeneic bone marrow transplantation in the treatment of 4 cases of congenital pure red cell aplasia, designed to pretransplant plan, efficacy and safety exploration. Patients and Methods Bone marrow donors are all HLA-identical, mixed lymphocyte culture (MLC) negative siblings or sisters. Recipients who have undergone long-term rule-based blood transfusions for at least 5 years are not eligible for treatment of idiopathic pure red cell aplasia