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微小RNA(miRNAs)是近年来发现的一类转录后调控mRNA翻译的非编码RNA,在生物的整个生命过程中发挥着重要作用。本文综述报道miRNAs的生物合成和调控,miRNAs在肺癌发生中的作用机制以及miRNAs与肺癌临床应用的研究进展。
MicroRNAs (miRNAs) are a class of non-coding RNAs that have been found in recent years to regulate posttranscriptional mRNA translation and play an important role in the life of an organism. This review summarizes the biosynthesis and regulation of miRNAs, the role of miRNAs in the pathogenesis of lung cancer, and the progress in the clinical application of miRNAs and lung cancer.