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目的 :探讨动态血压与尿微球蛋白和原发性高血压 (EH)肾损害的关系。方法 :2 4 h动态血压昼夜节律消失 (A组 )、节律正常 (B组 )各 30例 EH和 30例正常人 (对照组 )的血、尿 β2 微球蛋白 (β2 - MG) ,并对两组参数进行相关性分析。结果 :两组临床资料 ,偶测血压 (CBP) ,日间血压无显著差异 ,而血、尿 β2 - MG均较对照组高 (P<0 .0 0 1 )。尿 β2 - MG在早期时即出现异常 ;A组的 2 4小时血压、夜间血压、血压负荷及尿 β2 - MG均高于 B组 (P<0 .0 1 )。ABPM昼夜节律消失者 ,肾功能损害明显 ,而CBP不能揭示两组病人之间的这种差异。结论 :ABPM和尿 β2 - MG能更好地反映肾损害的关系 ,有利于早期肾损害的发现
Objective: To investigate the relationship between ambulatory blood pressure and urinary microglobulin and primary renal hypertension (EH). Methods: Blood and urinary β2 microglobulin (β2 - MG) were measured at 24 hours after disappearance of circadian rhythm of ambulatory blood pressure (group A), 30 cases of normal circadian rhythm (group B) and 30 normal controls (control group) Correlation analysis of two sets of parameters. Results: There was no significant difference between the two groups in clinical data, even measured blood pressure (CBP) and daytime blood pressure, while blood and urine β2 - MG were higher than those in control group (P <0.01). Urine β2 - MG was abnormal in the early stage; 24 hours blood pressure, nocturnal blood pressure, blood pressure and urinary β2 - MG in group A were higher than those in group B (P <0.01). ABPM circadian rhythm disappeared, renal dysfunction was obvious, and CBP can not reveal the difference between the two groups of patients. CONCLUSION: ABPM and urinary β2 - MG can better reflect the relationship between renal damage, is conducive to the discovery of early renal damage