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目的观察血浆置换(PE)治疗血栓性血小板减少性紫癜(TTP)的疗效。方法对2006年3月至2010年3月由我科确诊的12例TTP患者给予血浆置换联合糖皮质激素治疗。结果本组经治疗后有11例患者症状明显改善,1例死于脑梗死并发急性肾功能衰竭,总有效率为91.7%。血浆置换治疗后5 d血小板恢复正常。住院9～14 d后均好转出院。结论血浆置换辅助应用免疫疗法是临床治疗TTP的首选有效方法。
Objective To observe the efficacy of plasma exchange (PE) in the treatment of thrombotic thrombocytopenic purpura (TTP). Methods A total of 12 TTP patients diagnosed by our department from March 2006 to March 2010 were treated with plasma exchange combined with glucocorticoid. Results After treatment, the symptoms of 11 patients were significantly improved. One patient died of cerebral infarction complicated by acute renal failure, the total effective rate was 91.7%. Platelets returned to normal 5 days after plasmapheresis. 9 to 14 days after hospital admission improved. Conclusion Plasma exchange assisted immunotherapy is the first choice of effective clinical treatment of TTP.