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目的分析硫酸依替米星的药代动力学特点,为临床合理用药提供理想方案。方法广东省清远连州市人民医院2006年5月～2007年5月对20例健康老年志愿者进行了体内药代动力学研究,观察患者血药浓度、药代动力学及尿排出率等指标的变化,并与健康青年志愿者比较。结果与青年组相比,老年组患者药物半衰期明显延长,肾清除率及尿排出率降低、药时曲线下面积增大。结论老年人感染应用硫酸依替米星时需减少给药剂量和延长给药间期。
Objective To analyze the pharmacokinetic characteristics of etimicin sulfate and provide an ideal solution for clinical rational drug use. Methods In May 2006 ~ May 2007 in Lianzhou People’s Hospital of Qingyuan, Guangdong Province, 20 healthy elderly volunteers were studied for pharmacokinetics in vivo and the indexes of blood concentration, pharmacokinetics and urinary excretion rate were observed. The changes were compared with healthy young volunteers. Results Compared with the young group, the half-life of patients in the elderly group was significantly prolonged, the renal clearance rate and urinary excretion rate were decreased, and the area under the curve of the medicine time was increased. Conclusion Elderly patients infected with etimicin should reduce the dosage and extend the administration interval.