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目的探讨Abelson相关基因(Arg)在人大肠癌组织中的表达及其意义。方法免疫组织化学染色法检测80例大肠癌组织、30例癌旁大肠组织和30例大肠腺瘤中Arg的表达,并分析Arg表达水平与临床病理特征的相关性。结果 Arg在大肠癌组织中阳性表达率为70%,癌旁结肠组织和大肠腺瘤组织均无Arg表达。Arg表达与大肠癌的分化程度、浸润深度、淋巴结转移、TNM分期及癌胚抗原(CEA)水平有关(P<0.05),Arg高表达者生存期低(P<0.05)。结论 Arg可能在大肠癌发病过程中起重要作用,可作为大肠癌预后判断的有价值指标之一。
Objective To investigate the expression of Abelson related gene (Arg) in human colorectal carcinoma and its significance. Methods Immunohistochemical staining was used to detect the expression of Arg in 80 cases of colorectal carcinoma, 30 cases of colorectal carcinoma and 30 cases of colorectal adenoma. The correlation between Arg expression and clinicopathological features was analyzed. Results The positive expression rate of Arg in colorectal cancer was 70%, while there was no Arg expression in adjacent colorectal cancer and colorectal adenoma. The expression of Arg was correlated with the degree of differentiation, depth of invasion, lymph node metastasis, TNM stage and carcinoembryonic antigen (CEA) level in colorectal cancer (P <0.05). Conclusion Arg may play an important role in the pathogenesis of colorectal cancer and may be used as one of the valuable indicators in the prognosis of colorectal cancer.