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利用遗传流行病学的方法，调查了230个子女为青少年（6－16岁）的哮喘核心家系，分析了父或母对子女患哮喘和气道高反应性的影响。结果显示：在哮喘核心家系中，儿子比女儿更易患哮回与气道高反应性；与父母均无哮喘史家系的子女比较，父母亲的哮喘史将使子女患哮喘的危险性增加10-30倍（P＜0．01），其中母亲对子女的影响更为明显，是父亲对子女影响的两倍。父母的气道高反应性也显著增加子女气道高反应性的危险性（OR=2.49，P＜0．01）。不仅遗传因素是支气管哮喘的重要危险因素之一，而且气道高反应性与遗传因素密切相关。两者可能既有共同的遗传基础又有各自不同的遗传易感基因。
Using a genetic epidemiological approach, 230 nuclear pedigrees of children (6-16 years old) with asthma were investigated and their effects on children with asthma and airway hyperresponsiveness were analyzed. The results showed that in the nuclear pedigree of the asthma, the son was more susceptible to asthma and airway hyperresponsiveness than the daughter. Compared with the children whose parents had no history of asthma, the parents’ history of asthma increased their risk of developing asthma by 10- 30 times (P <0.01). Among them, mothers had more pronounced impact on their children and twice as much influence on their children. Parents’ airway hyperresponsiveness also significantly increased the risk of airway hyperresponsiveness (OR = 2.49, P <0.01). Not only genetic factors is one of the important risk factors for bronchial asthma, and airway hyperresponsiveness is closely related to genetic factors. Both may have both a common genetic basis and different genetic susceptibility genes.