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本综述主要介绍阿片和非阿片类镇痛药及临床研究的新进展。阿片受体及配体内源性阿片及其多种受体仍是大量研究的重点。近来阿片肽、阿片受体及其功能作用、脑啡肽和内啡肽的药理及治疗、内源性阿片类的心血管作用、阿片类化合物与肾上腺垂体轴、阿片与海马、感受伤害作用中的P 物质、阿片拮抗剂的潜在治疗作用、阿片肽对食欲的调控以及阿片受体的放射自显影技术均己有综述报道。
This review highlights the recent advances in opioid and non-opioid analgesics and clinical research. Opioid Receptors and Ligands Endogenous opioids and their receptors continue to be the focus of much research. Recent opioid peptides, opioid receptors and their functional roles, pharmacological and therapeutic enkephalin and endorphins, cardiovascular effects of endogenous opioids, opioid and adrenal pituitary axis, opiate and hippocampus, Of substance P, the potential therapeutic effect of opioid antagonists, opioid peptide regulation of appetite, and autoradiography of opioid receptors have all been reviewed.