已有报道糖尿病人较同年龄组人群相比骨病明显,其临床表现有骨质疏松、椎体或股骨颈骨折等。据认为发生这些改变的原因与糖尿病代谢控制有关。Levin 等曾注意到用口服降糖药治疗的糖尿病人其骨质损失较用胰岛素治疗病人明显。作者在1980年已观察到口服磺脲类降糖药(SU)病人骨代谢的生化指标异常。为探 It has been reported in patients with diabetes compared with the same age group of patients with obvious osteoporosis, the clinical manifestations of osteoporosis, vertebral fractures or femoral neck. The reason for these changes is believed to be related to the metabolic control of diabetes. Levin et al. Have noted that patients with diabetes treated with oral hypoglycemic agents have significantly less bone loss than those treated with insulin. The authors observed abnormal biochemical markers of bone metabolism in oral sulfonylureas (SU) patients in 1980. For exploration