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目的:观察慢性肾功能衰竭(CRF)患者血清中脂代谢水平的变化,探讨其与CRF的关系。方法:88例健康体检者为对照组,61例经临床确诊的CRF患者为观察组,采用全自动生化分析仪测定血清甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、TG/HDL-C、LDL-C/HDL-C、血清载脂蛋白A1(ApoA1)、载脂蛋白B(ApoB)、ApoA1/ApoB浓度;采用免疫透射比浊法测定脂蛋白a(L ipa)水平,并进行统计学分析。结果:观察组患者TG、LDL-C、TG/HDL-C、LDL-C/HDL-C、L ipa水平高于对照组,差异有统计学意义(P<0.01或P<0.05);HDL-C、APoA1、ApoA1/ApoB浓度低于对照组,差异有统计学意义(P<0.01);观察组患者血L ipa水平与血清ApoA1、ApoB及ApoA1/ApoB均无相关性。结论:CRF时脂代谢发生紊乱,血L ipa水平明显升高,是冠心病(CHD)、动脉粥样硬化(AS)的危险因子。是促进AS、并发缺血性心血管损害的重要因素。在肾病治疗过程中应控制脂代谢紊乱,防止或延缓心血管疾病、糖尿病等并发症发生。
Objective: To observe the changes of serum lipid levels in patients with chronic renal failure (CRF) and to explore its relationship with CRF. Methods: Eighty-eight healthy subjects were selected as the control group. Sixty-one clinically diagnosed CRF patients were selected as the observation group. Serum triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol LDL-C, HDL-C, TG / HDL-C, LDL-C / HDL-C, serum apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB), ApoAl / ApoB The levels of lipoprotein a (L ipa) were measured by immunoturbidimetry and analyzed statistically. Results: The levels of TG, LDL-C, TG / HDL-C, LDL-C / HDL-C and L ipa in the observation group were significantly higher than those in the control group (P <0.01 or P < C, APoA1 and ApoA1 / ApoB were lower than those in the control group (P <0.01). There was no correlation between the level of L ipa and serum ApoA1, ApoB and ApoA1 / ApoB in the observation group. CONCLUSIONS: Lipid metabolism is disturbed and blood L ipa levels are significantly elevated at CRF, which is a risk factor for coronary heart disease (CHD) and atherosclerosis (AS). Is to promote AS, complicated by ischemic cardiovascular damage an important factor. In the treatment of renal disease should control the lipid metabolism disorders, to prevent or delay cardiovascular disease, diabetes and other complications.