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目的 :研究乙脑的发病与内源性阿片肽的关系 ,以及阿片肽拮抗剂纳洛酮治疗乙脑的机制和疗效。方法 :治疗组 5 6例应用纳洛酮 0 .0 2mg (kg·次 ) ,每 6～ 8h 1次 ,3～ 5d ;对照组 5 0例未用 ,余治疗相同。观察疗效 ,同时检测急性期和恢复期的血浆和CSF内源性阿片肽含量。结果 :治疗组疗效显著 ,且急性期时血浆和CSF内源性阿片肽明显高于正常值 (P <0 .0 1 ) ,至恢复期时显著下降 (P <0 .0 1 ) ,治疗组比对照组下降更明显。结论 :乙脑的发病与内源性阿片肽释放增加有关 ,纳洛酮治疗后可使内源性阿片肽下降 ,是治疗乙脑的有效药物之一。
Objective: To study the relationship between the pathogenesis of encephalitis and endogenous opioid peptide and the mechanism and efficacy of naloxone, an opioid antagonist, for treating encephalitis. Methods: In the treatment group, 56 cases were treated with naloxone 0.2 mg (kg · min) once every 6 to 8 hours for 3 to 5 days. The control group of 50 cases was unused and the remaining treatment was the same. The curative effect was observed. Meanwhile, the content of endogenous opioid peptides in plasma and CSF in both acute and convalescent phase were detected. Results: The therapeutic effect of the treatment group was significant. In the acute phase, the levels of endogenous opioid peptides in plasma and CSF were significantly higher than normal (P <0.01), and significantly decreased in the recovery phase (P <0.01) Decreased more significantly than the control group. Conclusion: The incidence of Japanese encephalitis is related to the increase of endogenous opioid release. Naloxone treatment can decrease endogenous opioid peptide and is one of the effective drugs for treating JE.