秀丽隐杆线虫因其遗传背景清楚、个体结构简单、生活史短等特性,在遗传与发育生物学、行为与神经生物学、衰老与寿命、人类遗传性疾病、病原体与生物机体的相互作用、药物筛选、动物的应急反应、环境生物学和信号传导等领域得到广泛应用。近年来,该模式生物逐步应用于生态毒理学和卫生毒理学领域。本文从生物学背景资料、秀丽隐杆线虫研究历史、研究领域及成果、毒理学研究实验活动可能产生的危害、实验人员的相关风险等方面对秀丽隐杆线虫实验室生物安全 Due to its well-defined genetic background, simple structure and short life span, Caenorhabditis elegans is widely used in genetics and developmental biology, behavioral and neurobiology, aging and longevity, human genetic diseases, interactions between pathogens and biological organisms, Drug screening, animal emergency response, environmental biology and signaling and other fields are widely used. In recent years, the model organism gradually applied to the field of ecotoxicology and health toxicology. In this paper, the bio-safety of C. elegans from the background of biology, the research history, research fields and achievements of C. elegans, the possible harm of experimental activities of toxicological research and the related risks of laboratory workers,