膜性增生性肾小球肾炎(MPGN)的病理特征是肾小球广泛地受累、小叶增大呈鼓槌状,伴血管系膜细胞增多和血管系膜基质不同程度的硬化,肾小球基底膜(GBM)增厚及分层。临床上可表现为肾病综合征、急性出血性肾炎综合征,也可表现为隐袭性肾衰。经常可见低补体血症,但也可缺乏。本文认为MPGN是一个不同原因引起的病理性损害并且与几个临床病理单位有关。可分为两型。1.伴内皮下沉积物的MPGN:这一型除具有前述共同改变外,可见血管系膜基质或系膜细胞胞浆伸延至其邻近的毛细血管袢,致GBM呈分层表现。电镜见内皮下、分层的GBM间和血管系膜基质内均有沉积物。免疫荧光检查证明 Pathological features of membranoproliferative glomerulonephritis (MPGN) are extensive involvement of the glomeruli, lobular enlargement was drumstick-like, with increased mesangial cells and vascular mesangial matrix to varying degrees of hardening, glomerular basement Membrane (GBM) thickening and delamination. Clinically can be manifested as nephrotic syndrome, acute hemorrhagic nephritis syndrome, can also be expressed as cryptogenic renal failure. Often seen hypo-hyperlipidemia, but also lacking. This article suggests that MPGN is a pathological lesion caused by a different cause and is associated with several clinicopathological units. Can be divided into two types. 1. With subcutaneous sediment MPGN: This type in addition to the common changes in the above, we can see the blood vessels of mesangial matrix or mesangial cells extending to adjacent capillaries, causing GBM showed stratification. Electron microscopy see the endothelium, stratified GBM and vascular mesangial matrix have sediment. Immunofluorescence proved